Human Cancer Biology Distinct Signal Transduction Abnormalities and Erythropoietin Response in BoneMarrowHematopoietic Cell Subpopulations of Myelodysplastic Syndrome Patients
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Purpose: Myelodysplastic syndromes (MDS) are heterogeneous clonal diseases characterized by cytopenias as a result of ineffective hematopoiesis. Little is known about alterations in signal transduction
منابع مشابه
Signal transduction in MDS bone marrow populations DISTINCT SIGNAL TRANSDUCTION ABNORMALITIES AND ERYTHROPOIETIN RESPONSE IN BONE MARROW HEMATOPOIETIC CELL SUBPOPULATIONS OF MYELODYSPLASTIC SYNDROME PATIENTS
Purpose: Myelodysplastic syndromes (MDS) are heterogeneous clonal diseases characterized by cytopenias as a result of ineffective hematopoiesis. Little is known about alterations in signal transduction pathways in MDS. Experimental design: Multiparameter flow cytometry was used to evaluate the proteolytic activation of caspase-3 and the phosphorylation of ERK1/2, p38 MAPK, and STAT5 specificall...
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Patients with myelodysplastic syndrome (MDS) have ineffective in vivo and in vitro erythropoiesis, characterized by an impaired response to erythropoietin (Epo). We examined proliferation and maturation of MDS marrow cells in response to Epo in more detail. Epo-dependent DNA synthesis as well as induction of GATA-1 binding activity in marrow cells from 15 MDS cases were severely reduced as comp...
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Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...
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تاریخ انتشار 2012